The Complementary Role of 68Ga-DOTATATE PET/CT in Neuroblastoma

A girl diagnosed with neuroblastoma at 33 months underwent 123I-MIBG scan after surgery and chemoradiotherapy. Although MIBG scan showed complete response, the bone marrow biopsy showed refractory disease. Therefore, she underwent 68Ga-DOTATATE PET/CT, which revealed bone marrow involvement and 68Ga-DOTATATE–avid brain metastasis. Rare physiological pineal gland uptake was also depicted. 68Ga-DOTATATE PET/CT showed active progressive disease earlier, before it was detectable with MIBG scan. For patients with MIBG-negative relapsed/refractory disease, 68Ga-DOTATATE may have an important role in restaging, detecting unsuspected metastasis, therapy planning.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research