Dientamoeba fragilis in children: A systematic review on diagnostic considerations and efficacy of treatment.
Dientamoeba fragilis in children: A systematic review on diagnostic considerations and efficacy of treatment. Expert Rev Gastroenterol Hepatol. 2020 Mar 10;: Authors: van Kalleveen MW, van Gool T, Klarenbeek N, Benninga MA, Savelkoul PHM, de Meij T, Plötz FB Abstract Introduction: The presence of D. fragilis in feces is characterized by asymptomatic carrier ship to a spectrum of gastrointestinal symptoms. However, a causal relationship remains to be elucidated. In this systematic review we aimed to evaluate the relationship between eradication of D. fragilis and symptoms to establish the strength of evidence that D. fragilis in symptomatic children warrants antibiotic treatment.Areas covered: This systematic review covers a challenge in daily clinical practice. Is it necessary to test for D. fragilis in children with gastrointestinal symptoms and does a positive fecal PCR test warrant treatment?Expert opinion: Testing for D. fragilis seems justified in a selection of children with persistent unexplained chronic abdominal pain and diarrhea. Treatment of D. fragilis should be withhold until other causes like celiac disease have been excluded. Both microscopic and Real Time-PCR methods (or a combination of the two) can be used for diagnosis. Paromomycin or clioquinol are antibiotics of choice based on their small spectrum of activity, fewer side effects and better eradication rates than metronidazole. Future randomized studies, with strict inclusion cri...
Medtronic announces FDA approval of spinal cord stimulation therapy for treating chronic pain resulting from diabetic peripheral neuropathy /PRNewswire/ -- Medtronic plc (NYSE:MDT), a global leader in healthcare technology, today announced it has received U.S. Food and Drug Administration approval... www.prnewswire.com "Medtronic estimates that up to 800,000 US patients suffer from moderate to severe DPN symptoms that are not resolved through conventional medical management approaches, like drugs. The company views these patients as potential ...
A small pilot study suggests that an injection of a patient's own fat cells can help ease the often-excruciating heel pain brought on by a condition known as plantar fasciitis.
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