Combination Topical Chemotherapy for the Treatment of an Invasive Cutaneous Squamous Cell Carcinoma

Conclusion: Topical combination therapy with imiquimod, 5-FU, and tretinoin with intermittent, brief cryotherapy effectively treated a small, invasive SCC in this select patient who deferred surgery. Prospective randomized-controlled clinical trials to assess the role of combination topical treatment for invasive SCCs are warranted. J Drugs Dermatol. 2020;19(2)202-204. doi:10.36849/JDD.2020.2228 PMID: 32155018 [PubMed - as supplied by publisher]
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research

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A 51-year-old man with 30-year neurofibromatosis and 2-month elevated prostate-specific antigen and back pain underwent a 68Ga–prostate-specific membrane antigen (PSMA) PET/CT scan for possible prostate cancer. Prostate-specific membrane antigen PET/CT imaging showed no abnormal uptake of the prostate. However, in addition to PSMA uptake in his left lung, thorax, and right ilium, which was confirmed being a lung squamous cell carcinoma by a lung biopsy, widespread uptake was also observed in his skin fibroma lesions. This case demonstrates that benign neurofibromatosis could have uptake of PSMA.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Tongue cancer is often associated with pain and perineural invasion. The purpose of this study was to determine the association between tongue pain and otalgia and the microscopic identification of perineural invasion in patients with squamous cell carcinoma of the tongue.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
Conclusion: Although very rare, benign cyst from presacral space can become malignant transformation. This highlights the importance of pre-operative diagnostic tests and evaluation to correctly identify the source of the primary cancer, which is crucial prior to starting adjuvant therapy.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: mEHT did not cause unexpected CRT-related toxicities and is a safe treatment modality for HIV-positive patients, with minor limitations regarding body weight, even in a low-resource setting. PMID: 32180481 [PubMed - in process]
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
We report a retrospective single institution experience of the impact of prophylactic gabapentin (PG) on narcotic utilization in comparison to a historical non-PG control group.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Toxicity, Quality of Life, Survivorship, Costs of Care Source Type: research
This study compares historical rates of grade 3+ OM (35-40%) in HNC patients undergoing definitive concurrent CRT versus our cohort of patients with locally advanced head and neck squamous cell carcinoma (HNSCC) treated with prophylactic PBM.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Toxicity, Quality of Life, Survivorship, Costs of Care Source Type: research
The aim of this ongoing study was to examine Quality of Life (QoL) and pain in the first three months after trans-oral robotic surgery (TORS). Results will be available in November 2019. With the rising incidence of Human Papilloma Virus (HPV) induced oropharyngeal squamous cell carcinoma (OPSCC) this cancer has become the most frequently diagnosed head and neck cancer world-wide. Currently there are two main treatment options: radiotherapy (with or without chemotherapy) and TORS. TORS is still a relatively new treatment modality (approved by the FDA in 2000) and more research into outcomes, particularly functional and QoL outcomes is needed.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Toxicity, Quality of Life, Survivorship, Costs of Care Source Type: research
Conclusions: Surgery is one of the main steps in treating skin cancer. It has a great impact on patients' quality of life because of pain andthe effect on mobility and normal activities. Skin cancers influence the quality of life of patients both psychologicallyand physically. PMID: 32050413 [PubMed - in process]
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
Abstract BACKGROUND: Actinic keratosis (AK) is a common pre-malignant skin lesion that can progress to cutaneous squamous cell carcinoma (cSCC). Microwave therapy is an established cancer treatment and has been used for plantar viral warts. OBJECTIVES: To evaluate the efficacy and feasibility of microwave as a treatment for AK. METHODS: Stage 1 was a dose-setting study, where seven participants had the dielectric properties of 12 thick and 22 thin AK assessed for optimisation of the microwave dose used for treatment in Stage 2. Stage 2 was a randomised, internally-controlled trial evaluating 179 AK in 11...
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
We report the case of a 48 ‐year‐old man who presented with persistent right‐sided thoracic pain with chest computed tomography scan demonstrating a right‐sided pleural effusion and pleural mass invading the ribs. Ultrasound‐guided biopsy revealed a primary squamous cell carcinoma of the pleura. Positron emission to mography staging demonstrated metastatic lung and lymph node involvement precluding surgical therapy. Immunotherapy with nivolumab resulted in prolongation of survival with good quality of life. Malignant pleural effusions usually manifest in the course of metastatic cancer disease. Primary pleural tu...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
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