Transforming growth factor beta1 (TGFbeta1) in physiology and pathology.

Transforming growth factor beta1 (TGFbeta1) in physiology and pathology. Endokrynol Pol. 2013;64(5):384-96 Authors: Kajdaniuk D, Marek B, Borgiel-Marek H, Kos-Kudła B Abstract This review describes precisely the consequence of TGFbeta1 prevalence in the organism, and its significant influence on physiological and pathophysiological processes. Organ and tissue distinctiveness hinder unambiguous characterisation of the cytokine. However, there are constant functions of TGFbeta1 inducing no controversy: it participates in foetal development, control of cell growth and differentiation, induces fibrosis and scar formation (the process of 'wound healing'), causes the suppression of immune response, is involved in angiogenesis, the development of tumours, and inflammatory processes. Thus, TGFbeta1 is a multifunctional cytokine. There are three fundamental directions of its activities: I. TGFbeta1 regulates cell proliferation, growth, differentiation and cells movement. II. TGFbeta1 has immunomodulatory effects. III. TGFbeta1 has profibrogenic effects. TGFbeta1 action can be local and systemic. This review describes TGFbeta1 in pathology: colitis ulcerosa, Crohn's disease, coeliac disease, diabetic nephropathy, diabetic retinopathy and diabetic foot, pulmonary hypertension, and Alzheimer's disease. TGFv1 and its receptors are also of interest to endocrinologists. Lack of TGFb1-dependent growth control may result in oncogenesis: papillary, follicular ...
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research