A novel oxidative stress marker of atopic dermatitis in infants: thiol –disulfide balance

AbstractAtopic dermatitis (AD) is a chronic disease of infancy and its pathogenesis remains unclear. There are recent studies suggesting that oxidative stress could play a role in the pathophysiology of atopic dermatitis. The aim of this study was to evaluate thiol (SH) –disulfide (SS) hemostasis as a new marker of oxidative stress (OS) in infants with atopic dermatitis. Thirty-one infants with AD and 30 healthy infants were included in a prospective, cross-sectional study. PO-SCORAD Index of infants with atopic dermatitis was calculated at the time of sample col lection. Total antioxidant status (TAS), total oxidant status (TOS), native thiol (–SH), total thiol (–SH + –S–S–), and disulfide (SS) were measured in the control and patient groups. SS/SH, SS/total SH, SH/total SH ratios were compared between the groups. Mean native thiol and total t hiol concentrations of the patient group were lower than the control group (p = 0.012; 0.047). The mean disulfide concentration of the patient group was significantly higher than the control group (p = 0.025). SS/SH, SS/total SH, and SH/total SH ratios were significantly higher in the patient group than in the control group (p <  0.05). There was a positive correlation between the duration of the breasting of the patients and thiol concentrations (p = 0.000). In our study, we found increased oxidative stress and decreased antioxidant defense mechanisms in infants with AD. Dynamic thiol–disulfide bal...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research