In Vitro Antimicrobial Activity of Piper retrofractum Fruit Extracts against Microbial Pathogens Causing Infections in Human and Animals.
In Vitro Antimicrobial Activity of Piper retrofractum Fruit Extracts against Microbial Pathogens Causing Infections in Human and Animals. Int J Microbiol. 2020;2020:5638961 Authors: Panphut W, Budsabun T, Sangsuriya P Abstract Long pepper (Piper retrofractum Vahl) is a Thai medicinal herb which has been used as one of the common ingredients in variety of Thai foods. Here, we investigated antimicrobial activities of crude bioactive metabolites extracted from fruits of P. retrofractum against 10 pathogenic organisms (bacteria and yeast) causing opportunistic infections in human or animals including Bacillus subtilis ATCC6633, Staphylococcus aureus ATCC25923, Enterococcus faecalis ATCC2921, Escherichia coli ATCC25922, Klebsiella pneumonia TISTR1843, Pseudomonas aeruginosa ATCC741, Salmonella typhi (clinical isolate), Vibrio parahaemolyticus (XN98 and 5HP), and Candida albicans ATCC90020. The results of disk diffusion test showed that the extract from methanol solvent exhibited greater antibacterial activity than other solvents with inhibition zones ranging from 0.5 to 8.0 mm, respectively. Subsequently, minimal inhibition concentration (MIC) determined by the colorimetric assay confirmed that methanol extracts showed consistent results with disk diffusion method. In summary, in vitro assays suggest that methanol is the best solvent for extraction of bioactive metabolites from P. retrofractum fruits. This crude extract can inhibit the majority of human...
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Cordero, a 41-year-old Tony nominee, was initially hospitalized March 30 after developing pneumonia and later tested positive for the coronavirus.
Publication date: Available online 24 May 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Jia Liu, Yang Liu, Kexin Wu, Liben Pan, Zhong-Hua Tang
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Mohammad Reza Farahpour, Ehsan Pirkhezr, Ali Ashrafian, Ali Sonboli
Publication date: Available online 24 May 2020Source: Journal of Herbal MedicineAuthor(s): Maryam Hassanpour Moghadam, Zohreh Ghasemi, Samaneh Sepahi, Raheleh Rahbarian, Hooman Mosannen Mozaffari, Seyed Ahmad Mohajeri
Publication date: Available online 24 May 2020Source: EXPLOREAuthor(s): HongJuan Li, Haoming Huang, Wenjie Long, Junling Zuo, Hongqiang Huang
Authors: Worth LJ, Harrison SJ, Dickinson M, van Diemen A, Breen J, Harper S, Marshall C, Williamson DA, Thursky KA, Slavin MA PMID: 32447766 [PubMed - as supplied by publisher]
In conclusion, we demonstrated that the selective boosting of lung innate immunity is a conceptually advantageous approach for improving the effectiveness of antibiotic treatment and fighting antibiotic-resistant bacteria. Introduction Pneumonia constitutes a major cause of death, morbidity and health resource use worldwide. The main causative agents identified in adult patients hospitalized for community-acquired pneumonia (CAP) are viruses (in 27–30% of cases, the most common being rhinovirus, influenza and coronavirus) and bacteria (14–23% of cases, with a marked predominance of Streptococcus pneumonia...
Conclusions/implications While bismuth subsalicylate, and bismuth tribromophenate unbound to Xeroform® demonstrate antimicrobial activity, it appears that Xeroform® dressings do not. The utility of Xeroform® in burn medicine may relate more to use as an impervious dressing than to antimicrobial effect. Donor sites are clean surgical wounds and clean partial thickness burns may have minimal colonization present. In such circumstances, an inactive and impervious dressing may be all that is necessary to promote wound healing. Graphical abstract