Attenuated isolated 3 ’ signal: a highly challenging therapy relevant ALK FISH pattern in NSCLC

Lung cancer is the leading cause of cancer death in the developed world. Targeted therapy in non-small cell lung cancer (NSCLC) reshaped the landscape of thoracic oncology. Among numerous identified driver mutations in NSCLC, several genetic abnormalities - resulting in activated and/or overexpressed oncoproteins (including EGFR, ALK, ROS1, BRAF) - are already druggable [1]. A paracentric chromosomal inversion (inv(2)(p21;p23)) affecting the genes echinoderm microtubule-associated protein like 4 (EML4) and anaplastic lymphoma kinase (ALK), both located on the short arm of chromosome 2 is one such abnormality that is detectable with different methods.

Source: Lung Cancer - March 9, 2020 Category: Cancer & Oncology Authors: G ábor Smuk, Gábor Pajor, Károly Szuhai, Hans Morreau, Ildikó Kocsmár, Éva Kocsmár, László Pajor, Béla Kajtár, Veronika Sárosi, Gábor Lotz, Tamás Tornóczky Source Type: research