Vitamin D status and the immune assessment in 22q11.2 deletion syndrome.

Vitamin D status and the immune assessment in 22q11.2 deletion syndrome. Clin Exp Immunol. 2020 Mar 09;: Authors: Legitimo A, Bertini V, Costagliola G, Baroncelli GI, Morganti R, Valetto A, Consolini R Abstract 22q11.2 deletion syndrome (22q11.2DS) is characterized by a heterogeneous phenotype, including alterations in phospho-calcium metabolism and immunodeficiency. We analyzed vitamin D status and the immune assessment, focusing on T cell subpopulations and dendritic cells (DCs) in a cohort of 17 pediatric 22q11.2DS patients and 17 age-matched healthy subjects. As antigen presenting cells, DCs are the main target of vitamin D, promoting a tolerogenic T-cell response. Patients were subdivided into three groups according to the parameters of phospho-calcium metabolism and serum levels of 25OHD: normal values, vitamin D deficiency, and hypoparathyroidism. Different degrees of T cell deficiency, ranging from normal/partial T cell number were observed in the cohort of patients. The group with vitamin D deficiency showed a significant reduction of naïve T cells and a significant increase of central memory T cells compared to controls. In this group the number of circulating DCs was significantly reduced. DC decrease affected both myeloid and plasmacytoid DC subsets (mDCs and pDCs), with the most relevant reduction involving pDCs. A direct correlation between 25OHD levels and recent thymic emigrant (RTE) and DC number was identified. Des...
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research