Genetic and pharmacological targeting of A2a receptor improves function of anti-mesothelin CAR T cells

CAR T cell-based therapies have shown promising results in hematological malignancies. Results of CAR T cell projects in solid tumors have been less impressive, and factors including lack of targetable antigen...

Source: Journal of Experimental and Clinical Cancer Research - March 10, 2020 Category: Cancer & Oncology Authors: Elham Masoumi, Leila Jafarzadeh, Hamid Reza Mirzaei, Khadijeh Alishah, Keyvan Fallah-Mehrjardi, Hosein Rostamian, Mohammad Khakpoor-Koosheh, Reza Meshkani, Farshid Noorbakhsh and Jamshid Hadjati Tags: Research Source Type: research