Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis

Conclusions Systemic C5a is elevated in pneumonia patients. Neutralizing C5a protected against lung and liver injury in pneumococcal pneumonia in mice. Early neutralization of C5a might be a promising adjunctive treatment strategy to improve outcome in community-acquired pneumonia.Editor ’s PerspectiveWhat We Already Know about This TopicPneumonia, sepsis, and immune dysregulation cause morbidity and mortalityC5a is a component of the complement system and a proinflammatory mediator that modulates the innate immune response in critical illnessDisruption of the C5a receptor axis with antibodies or antagonists was previously protective in various animal sepsis modelsWhat This Article Tells Us That Is NewIn hospitalized patients with community-acquired pneumonia, serum C5a concentrations were 1.4-fold higher compared to healthy subjectsIn two mouse models of pneumonia and sepsis, NOX-D19, a C5a-neutralizingl-RNA-aptamer, caused lower pulmonary hyperpermeability and sepsis-related acute liver injury
Source: Anesthesiology - Category: Anesthesiology Source Type: research