miR-345 inhibits migration and stem-like cell phenotype in gastric cancer via inactivation of Rac1 by targeting EPS8.

In conclusion, miR-345 plays an inhibitory role in GC metastasis through inhibiting cell migration, EMT, and cancer stem cell phenotype via inactivation of Rac1 signaling by targeting EPS8, which provides the potential therapeutic and predictive value of miR-345 in GC. PMID: 32147678 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32147678?dopt=Abstract

Source: Acta Biochimica et Biophysica Sinica - March 5, 2020 Category: Biochemistry Authors: Zhang J, Wang C, Yan S, Yang Y, Zhang X, Guo W Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research