Nicotinic Acetylcholine Receptor Density in the “Higher-Order” Thalamus Projecting to the Prefrontal Cortex in Humans: a PET Study

ConclusionsThis particular neurochemical organization of the thalamus supports a major role of the cholinergic system in the loops between the thalamus and the prefrontal cortex. The highest nicotinic acetylcholine receptor density in the « higher-order thalamus » could partly explain the beneficial effect of acute nicotine on attentional and executive functions and possibly the pathophysiology of some neuropsychiatric disorders.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research

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CONCLUSION: This study seems to depict the existence of resting state hippocampo-lingual functional network which correlates well with lateralization of language function in the left hemisphere in both temporal lobe epilepsy patients and healthy controls. PMID: 32490643 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
CONCLUSIONS: Altered regional activity in DRE patients was reorganized after 3 months of stimulation. Increased ReHo in the right superior or middle temporal gyrus was implicated in VNS-induced improvement in seizure frequency. PMID: 32479850 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
Abstract Epilepsy is a complex and multifactorial neurodegenerative disease described by recurrent seizures. Oxidative stress and dysregulation of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) are critical factors for the development of epilepsy. Daidzin is well-known for its effective anti-inflammatory and antioxidant potential for centuries. The present study was focused on exploring the anti-epileptic potential of daidzin in the pentylenetetrazole-induced mice model. Daidzin (1, 5, and 10 mg/kg) was administered in the acute study and the dose was optimized. Pretr...
Source: Neurotoxicology - Category: Neurology Authors: Tags: Neurotoxicology Source Type: research
Conclusion: Anti-GABA-B receptor encephalitis mainly occurred in middle-aged and elderly men, and the disease onset was relatively sudden. Before disease onset, some patients experienced fever and non-specific respiratory symptoms, which mainly manifested as frequent epileptic seizures, cognitive dysfunction, and abnormal mental behavior. MRI and PET-CT revealed abnormal signals and local metabolism, respectively, in the temporal lobe. Moreover, the disease has a close relationship with lung cancer, which requires long-term follow-up observation.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
CONCLUSIONS: Our results suggest that dexmedetomidine-based protocol provides reliable sedation in children undergoing MEG scanning because of the high success rate, limited interictal artifacts, and minimal impacts on spike frequency. PMID: 32436319 [PubMed - as supplied by publisher]
Source: Paediatric Anaesthesia - Category: Anesthesiology Authors: Tags: Paediatr Anaesth Source Type: research
AbstractThis review updates the radiologist on current epilepsy surgery practice in children, with a specific focus on the role of imaging in pre-surgical work-up, current and novel surgical techniques, expected post-surgical imaging appearances and important post-operative complications. A comprehensive review of the current and emerging international practices in paediatric epilepsy surgical planning and post-operative imaging is provided with details on case-based radiological findings. A detailed discussion of the pathophysiology and imaging features of different epileptogenic lesions will not be discussed as this is n...
Source: Neuroradiology - Category: Radiology Source Type: research
Ramesh S Doddamani, Manjari Tripathi, Raghu Samala, Mohit Agarwal, Bhargavi Ramanujan, Sarat P ChandraNeurology India 2020 68(2):270-273 The posterior quadratic epilepsy (PQE) is a form of a multilobar epilepsy, involving the temporal-parietal and occipital lobes. Basically, epilepsies with localized networks to the posterior temporal, posterior parietal, and occipital lobes can benefit from this type of surgery. Gliosis due to perinatal insult and cortical dysplasis and angiomas in Sturge Weber syndrome involving the PQ have often been cited in the literature as the etiology for PQE. However, before considering surgery, ...
Source: Neurology India - Category: Neurology Authors: Source Type: research
3039Objectives: Altered functional activities and hypometabolism have been found within the ipsilateral hippocampal network in medial temporal lobe epilepsy patients with hippocampal sclerosis (mTLE-HS). Hybrid PET/MR scanners provide opportunities to explore the relationship between resting-state energy consumption and functional activities, but whether the repeated seizures could disturb the bioenergetic coupling and its relation with seizure outcome is not known in patients with mTLE-HS. In this prospective study, twenty-six patients with mTLE-HS and twenty-six healthy controls from March 2016 to May 2018 were performed...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Tech Papers V: Cardiovascular Science & amp; Neuroscience Technologist Papers Source Type: research
Conclusions: Ictal-interictal SPECT provides a noninvasive option for presurgical analysis of epileptogenic focus. To ensure accurate SPECT images are acquired, the radioisotope injection must begin as close to the onset of a patient’s seizure as possible. The clinical onset typically differs from the EEG onset times, and this study showed a six second difference of mean times. The ictal injection challenges and variance of onset times lead us to believe discrepancies could be found in ictal-interictal SPECT findings with further analysis.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Technologist Poster Session Source Type: research
398Objectives: We sought to investigate the contribution of delayed 18F-FDG imaging data to epileptogenic zone (EZ) identification using a hybrid positron emission tomography / magnetic resonance imaging (PET/MR) system. Methods: Forty-one patients> 12 y with epilepsy underwent a brain dual time point 18F-FDG PET/MRI examination. The patients were divided into: (1) MR-positive (signal/structural abnormalities)/MR-negative depend on MRI findings; (2) extra temporal lobe epilepsy (extra-TLE)/temporal lobe epilepsy (TLE) depend on EZ localization; (3) short delayed (150.1 ± 20.2 min)/long delayed (247.8 ± 24....
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Wide World of Neuroimaging Source Type: research
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