Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb

Microglia play key roles in regulating synapse development and refinement in the developing brain, but it is unknown whether they are similarly involved during adult neurogenesis. By transiently depleting microglia from the healthy adult mouse brain, we show that microglia are necessary for the normal functional development of adult-born granule cells (abGCs) in the olfactory bulb. Microglial depletion reduces the odor responses of developing, but not preexisting GCs in vivo in both awake and anesthetized mice. Microglia preferentially target their motile processes to interact with mushroom spines on abGCs, and when microglia are absent, abGCs develop smaller spines and receive weaker excitatory synaptic inputs. These results suggest that microglia promote the development of excitatory synapses onto developing abGCs, which may impact the function of these cells in the olfactory circuit.
Source: eLife - Category: Biomedical Science Tags: Neuroscience Source Type: research

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Publication date: Available online 3 June 2020Source: Annals of Medicine and SurgeryAuthor(s): Rami Alqassieh, Mahmoud Al-Balas, Hamzeh Al-Balas
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
This study was conducted to compare the anesthetic and analgesic efficacy of bupivacaine with other local anesthetic agents routinely used for mandibular third molar surgery.Method and materials: Four electronic databases (PubMed, Scopus, Cochrane, and Web of Science) were explored to isolate randomized controlled trials up to 10 February 2019. The anesthetic and analgesic efficacies were assessed using six evaluation outcomes: onset of anesthesia, success of anesthesia, duration of anesthesia, duration of analgesia, pain score on the fourth postoperative hour, and number of analgesics consumed. Stata software (version 13,...
Source: Quintessence International - Category: Dentistry Source Type: research
Publication date: Available online 4 June 2020Source: Journal of Dental SciencesAuthor(s): Tshering Samdrup, Kanittha Kijsamanmith, Kadkao Vongsavan, Praphasri Rirattanapong, Noppakun Vongsavan
Source: Journal of Dental Sciences - Category: Dentistry Source Type: research
CONCLUSION: In this study, we found a strong correlation between ScvO2 and NIRS measurements taken from the internal jugular vein site. Accordingly, continuous noninvasive monitoring with transcutaneous NIRSijv can be an alternative method as a trend monitor for the central venous oxygen saturation in pediatric cardiac patients undergoing congenital cardiac surgery. PMID: 32490634 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Authors: Keneisenuo K, Choudhary OP, Priyanka P, Kalita PC, Kalita A, Doley PJ, Chaudhary JK Abstract There is no previously reported information on the applied anatomy and clinical significance of the maxillofacial and mandibular regions of the barking deer and sambar deer. Therefore, the present study was designed to provide some important clinical landmarks related to tracking of the infraorbital, mental and mandibular nerves with its clinical implications in regional anaesthesia in both the species. In the present study, the distance between the most lateral bulging of the facial tuberosity to the infraorbital ...
Source: Folia Morphologica - Category: Anatomy Tags: Folia Morphol (Warsz) Source Type: research
In this study, it was aimed to examine the forelimb arteries in Southern Karaman and Hasak sheep breeds. Totally 8 Southern Karaman and 8 Hasak sheep were obtained from Konya Bahri Dagdas International Agricultural Institute. The sheep were anesthetized with xylazine and ketamine and extravasated by cutting the arteria carotis communis in the neck area of the sheep. The forelimbs of the sheep separated from the body were fixed in 10% formaldehyde solution and then dissections were made and the course and branching of the arteries were examined. It was determined that the arteria brachialis was divided into two main branche...
Source: Folia Morphologica - Category: Anatomy Tags: Folia Morphol (Warsz) Source Type: research
Conclusions: Compared with ACR, MUA provided equivalent clinical outcomes in the early period after procedure. Our study suggests that MUA is a useful option to be considered as treatment for refractory AC before choosing ACR. PMID: 32489544 [PubMed - in process]
Source: Clinics in Orthopedic Surgery - Category: Orthopaedics Tags: Clin Orthop Surg Source Type: research
Authors: Somri M, Gaitini L, Safadi A, Hossein J, Ebraheem N, Gat M, Gómez-Ríos MÁ PMID: 32490609 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Authors: Stamenkovic DM, Selvaraj S, Venkatraman S, Arshad A, Rancic NK, Dragojevic-Simic VM, Miljkovic MN, Cattano D Abstract The physical and psychological fragility of patients with psychiatric illness poses critical importance in the preoperative assessment, evaluation, and choice of premedication, which includes regular therapy, as well as concerns about polypharmacy with possible interactions of anesthetics, analgesics, and psychiatric medications. A considerable effort is to reduce risks for exacerbations or relapses of imminent illness in the postoperative period. In this narrative review, the goal was also...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Authors: Rahimzadeh P, Mahmoudi K, Khodaverdi M, Faiz SHR Abstract Introduction: Laparoscopic gynecologic surgery is one of the most well-known procedures. Pneumoperitoneum with carbon dioxide insufflation can cause unfavorable hemodynamic effects due to catecholamine and vasopressin release. Aim: To examine the effects of stellate ganglion block on hemodynamic response and postoperative pain. Material and methods: In a prospective double blinded randomized parallel study we included 40 patients with ASA physical status I and II, aged between 18 and 50 years with a gynecologic problem candidate for laparosc...
Source: Videosurgery and Other Miniinvasive Techniques - Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research
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