[Is hypoxia a factor in the progression of pulmonary sarcoidosis?]

[Is hypoxia a factor in the progression of pulmonary sarcoidosis?] Rev Mal Respir. 2020 Mar 04;: Authors: Jeny F, Bernaudin JF, Valeyre D, Nunes H, Planès C, Besnard V Abstract Sarcoidosis is a systemic granulomatous disease that can reduce life expectancy mainly due to pulmonary fibrosis resulting from granulomatous inflammation The lack of vascularization within pulmonary granulomas suggests that macrophages localized in the center of these structures are hypoxic. Hypoxia signaling pathways are known to be pro-inflammatory and pro-fibrotic in various pathological conditions. Recent data suggest an involvement of the transcription factor hypoxia-inducible factor (HIF) in the pathogenesis of sarcoidosis. This could represent a new research approach for the understanding and therapeutic management of sarcoidosis. PMID: 32146058 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research