One million people call NHS coronavirus support line

Meanwhile new legislation will make it easier for volunteers to help the NHS Related items fromOnMedica Safeguarding: what lies ahead for 2019 How a ‘grumpy’ GP can have a disproportionate effect on a young person’s health Helping GPs to help people live the life they want through a more personalised care approach Measles warning as vaccination rates fall Should we recognise obesity as a disease?
Source: OnMedica Latest News - Category: UK Health Source Type: news

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Authors: Barber MRW, Clarke AE Abstract INTRODUCTION: Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects almost every organ system and it is treated with immunomodulation and immunosuppression. SLE patients have an intrinsically dysfunctional immune system which is exacerbated by disease activity and leaves them vulnerable to infection. Treatment with immunosuppression increases susceptibility to infection, while hydroxychloroquine use decreases this risk. Infectious diseases are a leading cause of hospitalization and death. AREAS COVERED: This narrative review provides an overview of rec...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
We examined 4 pathologic conditions of IR in humans to examine pathways controlling lipid metabolism and gluconeogenesis.METHODS Cross-sectional study of severe receptor IR (INSR, n = 7) versus postreceptor IR that was severe (lipodystrophy, n = 14), moderate (type 2 diabetes, n = 9), or mild (obesity, n = 8). Lipolysis (glycerol turnover), hepatic glucose production (HGP), gluconeogenesis (deuterium incorporation from body water into glucose), hepatic triglyceride (magnetic resonance spectroscopy), and hepatic fat oxidation (plasma β-hydroxybutyrate) were measured.RESULTS Lipolysis was 2- to 3-fold higher in INSR ver...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Enteric neuronal degeneration, as seen in inflammatory bowel disease, obesity, and diabetes, can lead to gastrointestinal dysmotility. Pyroptosis is a novel form of programmed cell death but little is known about its role in enteric neuronal degeneration. We observed higher levels of cleaved caspase-1, a marker of pyroptosis, in myenteric ganglia of overweight and obese human subjects compared with normal-weight subjects. Western diet–fed (WD-fed) mice exhibited increased myenteric neuronal pyroptosis, delayed colonic transit, and impaired electric field stimulation–induced colonic relaxation responses. WD incr...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Cases in Africa pass 150,000; Germany eases travel ban;Wuhan doctor who worked with whistleblower diesGermany lifts travel warning for EuropeChina withheld data on coronavirus from WHO, recordings reveal‘We can’t relax’: Europeans face up to life after lockdownUK coronavirus updates – liveCoronavirus latest: at a glance9.00pmBSTKey developments in the globalcoronavirus outbreak today include:8.52pmBSTThe USA has confirmed 14,790 more cases and 761 more deaths in the past 24 hours, according to the Centers for Disease Control and Prevention (CDC). That takes the cumulative totals to 1,802,470 and 105...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Infectious diseases Science Microbiology Medical research UK news US news Australia news Source Type: news
Athletes who test positive for SARS-CoV-2, the virus that causes COVID-19, should take at least two weeks off from intense or competitive exercise and even more if they show signs of myocarditis, according to two new reports.Reuters Health Information
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Infectious Diseases News Source Type: news
Infants with symptomatic COVID-19 infection harbor higher SARS-CoV-2 viral loads in the nose at presentation but develop less severe disease as compared to older children and adolescents, report clinicians from New York City.Reuters Health Information
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Pediatrics News Source Type: news
Authors: Alanagreh L, Alzoughool F, Atoum M Abstract The emerging COVID-19 pandemic poses a threat to the global health care system. Given the lack of antiviral therapies or vaccines for the disease, the antimalarial drug hydroxychloroquine (HCQ) obtained much attention as a treatment for COVID-19. However, there are limited and uncertain clinical data to support the beneficial effect of this drug in COVID-19 treatment. HCQ has several side effects and warnings, including blindness, heart failure, and renal toxicity, even with recommended doses. For severe cases of COVID-19 or in patients with preexisting condition...
Source: International Journal of Risk and Safety in Medicine - Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research
Authors: Doggrell SA Abstract INTRODUCTION: Lopinavir in combination with ritonavir is approved for the treatment of HIV and has recently been subject to a clinical trial in severe Covid-19. AREAS COVERED: This evaluation is of LOTUS China (the Lopinavir Trial for Suppression of SARS-Cov-2 in China), which was a randomised trial in hospitalised subjects with Covid-9 in a respiratory sample and pneumonia. As, in severe Covid-19, lopinavir/ritonavir had no beneficial effects but increased gastrointestinal adverse effects, this combination should not be used at this stage of Covid-19. EXPERT OPINION: In my opi...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
The new nonprofit, named Beacon, aims to highlight and protect the legal rights of medical professionals who speak out about PPE supply and other matters of public concern related to COVID-19.Medscape Medical News
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Infectious Diseases News Source Type: news
Will everyone get coronavirus eventually? If so, is there a strategy to get us through this pandemic as quickly as possible without leading to excess deaths?Medscape
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Infectious Diseases Commentary Source Type: news
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