The 'London patient' who was CURED of HIV reveals his identity

Adam Castillejo, 40, was known only as the 'London patient' until today. He was anonymised by doctors who revealed he had been cured of HIV after having a bone marrow transplant for blood cancer.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Authors: Pablo A, Breaud AR, Clarke W Abstract Bone marrow transplantation is used to treat particular types of cancers such as lymphoma, leukemia, and multiple myeloma. Appropriate dosing of busulfan during the preparative phase is critical for a successful allograft; if blood concentrations get too high significant liver toxicity can occur, if blood concentrations are too low, then graft-versus-host disease (GVHD) can develop. Busulfan monitoring in blood allows hospitals with the opportunity to provide individualized medicine to patients and improve overall patient outcome. Liquid Chromatography-Tandem Mass Spec...
Source: Current Protocols in Toxicology - Category: Toxicology Tags: Curr Protoc Toxicol Source Type: research
Conclusions: The SR-A1-c-Myc axis may represent a promising target to treat DiCM through augmentation of cardiac resident reparative macrophage proliferation. PMID: 32466726 [PubMed - as supplied by publisher]
Source: Circulation Research - Category: Cardiology Authors: Tags: Circ Res Source Type: research
Abstract OBJECTIVE: The aim of this study was to identify risk factors for the development of severe dry eye syndrome (DES) in patients with ocular graft-versus-host disease (oGVHD). DESIGN: Retrospective Chart Review. PARTICIPANTS: Patients undergoing allogeneic hematopoietic stem cell transplantation at the British Columbia Cancer Agency between 2011 and 2013. METHODS: A retrospective chart review of post-transplant patients with oGVHD DES followed at the British Columbia Cancer Agency Bone Marrow Transplant Unit was performed. Patient and donor data were collected. Descriptive and inferential sta...
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
Abstract INTRODUCTION: A pandemic coronavirus, SARS-CoV-2, causes COVID-19, a potentially life-threatening respiratory disease. Patients with cancer may have compromised immunity due to their malignancy and/or treatment, and may be at elevated risk of severe COVID-19. Community transmission of COVID-19 could overwhelm health care services, compromising delivery of cancer care. This interim consensus guidance provides advice for clinicians managing patients with cancer during the pandemic. MAIN RECOMMENDATIONS: During the COVID-19 pandemic: In patients with cancer with fever and/or respiratory symptoms, consid...
Source: Med J Aust - Category: General Medicine Authors: Tags: Med J Aust Source Type: research
Pulmonary manifestations of systemic disease occur in a wide range of conditions including, most commonly, connective tissue diseases such as scleroderma and rheumatoid arthritis. Certain haematological malignancies are associated with acquired pulmonary alveolar proteinosis. Treatment of myelo-lymphoproliferative diseases with bone marrow transplantation can itself cause obliterative bronchiolitis as part of a graft-versus-host response. Infectious pathologies such as HIV disease can predispose to opportunistic lung infection, pulmonary lymphoid disorders and cancer.
Source: Medicine - Category: Internal Medicine Authors: Tags: Systemic and parenchymal lung diseases Source Type: research
Abstract The leukaemias are a heterogenous group of blood cancers which, together, caused 310,000 deaths in 2016. Despite significant research into their biology and therapeutics leukaemia is predicted to account for an increased 470,000 deaths in 2040. Many subtypes remain without targeted therapy, and therefore the mainstay of treatment remains generic cytotoxic drugs with bone marrow transplant the sole definitive option. In this review, we will focus on cellular mechanisms which have the potential for therapeutic exploitation to specifically target and treat this devastating disease. We will bring together the...
Source: Current Cancer Drug Targets - Category: Cancer & Oncology Authors: Tags: Curr Cancer Drug Targets Source Type: research
In an analysis of the outcome of pediatric acute myeloid leukemia (AML) with FMS-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutation over 10 years at Children ’s Cancer Hospital Egypt, we found that FLT3-ITD mutation was associated with poor outcomes, and survival of patients who experienced relapse was extremely poor. Allogeneic bone marrow transplantation while the patient is experiencing first remission was the best treatment option. FLT3 inhibitors are needed to improve the outcome in AML in developing countries.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
Floyd Rohan Not only do racial and ethnic minority children and adolescents with chronic illness experience disparities in health status and health outcomes, they also experience significant healthcare disparities, including differences in healthcare coverage, access to care, and quality of care. It is well known that the interaction between psychosocial functioning, health behaviors and ethnic and racial disparities, ultimately leads to worse health and psychosocial outcomes in pediatric and AYA chronic illness patient populations, including increased rates of morbidity and mortality. Investigating the impact of ra...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Commentary Source Type: research
The American Society for Transplantation and Cellular Therapy position statement on measles-mumps-rubella (MMR) prevention in immunocompromised cancer and hematopoietic cell transplant patients by Pergam et al. [1] addresses many concerns both providers and patients have about measles prevention post-transplant. However, we are skeptical about the data regarding the safety of the MMR vaccination guidelines for patients after allogenic bone marrow transplant as stated in this article.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
The American Society for Transplantation and Cellular Therapy position statement on MMR prevention in immunocompromised cancer and hematopoietic cell transplantation (HCT) patients by Pergam et. al. addresses many of the concerns both providers and patients have about Measles prevention post-transplant.1 However, we are skeptical about the data regarding the safety of the MMR vaccination guidelines for post-allogenic bone marrow transplant patients as stated in this article.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
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