Altered morphology and function of the peripheral nociceptive system in the offspring of diabetic rats.

Altered morphology and function of the peripheral nociceptive system in the offspring of diabetic rats. Int J Dev Neurosci. 2020 Mar 06;: Authors: Lima TC, Paes Lemes JB, Capop TFPA, de Lima LB, da Cruz Lotufo CM Abstract The aim of this study was to determine whether maternal diabetes induced by alloxan injection in the first gestational day of female Wistar rats interfere with the development of the nociceptive peripheral system of the offspring. Behavioral and histologic analysis was performed using the adult offspring of diabetic and control rats. It was found that the offspring of diabetic rats were more sensitive to thermal stimulation, and showed an altered response to carrageenan induced inflammatory hyperalgesia. The histological analysis showed an increased proportion of nociceptive neurons while the population of non-nociceptive myelinated neurons was reduced. Therefore exposition to hyperglycemia and/or hyperinsulinemia in uterus, caused by a diabetic mother, might result in altered nociceptive sensations in the offspring throughout life. PMID: 32144810 [PubMed - as supplied by publisher]
Source: International Journal of Developmental Neuroscience - Category: Neuroscience Authors: Tags: Int J Dev Neurosci Source Type: research