IJERPH, Vol. 17, Pages 1762: Decreased Risk of Renal Calculi in Patients Receiving Androgen Deprivation Therapy for Prostate Cancer
In conclusion, ADT patients had approximately one-third lower risk of subsequent renal calculi. Further studies are warranted to evaluate the clinical significance.
ConclusionsLMICs lack enough training opportunities and urologists to care for their population. There is disconnect between the needs identified by local and visiting urologists. International collaborations should target broader interventions in LMICs to address local priorities such as diagnostic studies, support staff and financial support.
The opioid epidemic claimed the lives of 70,237 Americans in 2017.1 To put that in perspective, it is more than twice as many Americans who died from prostate cancer in 2016.1 Urolithiasis is also a common condition affecting 1 out of every 11 people in the United States and is often treated with opioids.2 In 2009, the National Inpatient Sample showed that 15,409 inpatient ureteroscopies were performed.3 In the United States, it is commonplace for urologists to prescribe opioids after ureteroscopy.
ConclusionsThe continuous incorporation of clinical data, further ML and DL algorithm retraining, and generalizability of models will augment the prediction accuracy and enhance individualized medicine.
ConclusionsSmartphone technology is constantly evolving and has the potential to improve urological care and education. Of concern to consumer and urologist alike is that these downloadable programs are limited due to the accuracy of their content, risk of confidentiality breach, and the lack of central regulation and professional involvement in their development.
Publication date: Available online 28 September 2019Source: Acta Pharmaceutica Sinica BAuthor(s): Vincent Blay, Mu-Chun Li, Sunita P. Ho, Mashall L. Stoller, Hsing-Pang Hsieh, Douglas R. HoustonAbstractHepsin, a transmembrane serine protease abundant in renal endothelial cells, is a promising therapeutic target against several cancers, particularly prostate cancer. It is involved in the release and polymerization of uromodulin in the urine, which plays a role in kidney stone formation. In this work, we design new potential hepsin inhibitors for high activity, improved specificity towards hepsin, and promising ADMET propert...
ConclusionDipstick urinalysis did not markedly increase the detection of undiagnosed medically important conditions that cause/contribute to urinary symptoms, suggesting that this test may not be a very effective screening tool for men with LUTS.FundingBoehringer Ingelheim Pharmaceuticals, Inc.
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
This study aims to identify if cancer is a risk factor for the development of UTC.MethodsA population-based retrospective cohort study was conducted for the period 1st January 1990 to 1st May 2016. 124,901 exposed patients identified using clinical codes with newly diagnosed cancer were matched to 476,203 unexposed controls by age, gender, BMI, and general practice. The main outcome measure was the risk of developing UTC described by hazard ratios.ResultsThere were 512 incident UTC events in the cancer group compared to 1787 in the unexposed controls. This translated to an adjusted hazard ratio of 1.26 (95% CI 1.14 –1.39;p
Urologic disease is a major contributor to morbidity and health care costs in the United States. A recent National Health and Nutrition Examination Survey indicates the prevalence of kidney stones among US adults has risen to 10%, and it is estimated that some degree of urinary incontinence affects 30% of the population.1 According to Surveillance, Epidemiology, and End Results estimates 11.2% of US adults will be diagnosed with prostate cancer, 2.3% with bladder cancer, and 1.7% with kidney cancer over their lifetime.
Conditions: Prostate Cancer; Benign Prostatic Hypertrophy; Bladder Stones; Kidney Stones Intervention: Diagnostic Test: NV-VPAC1 PCa Urine Diagnostic Test Sponsors: Intermountain Health Care, Inc.; NuView Diagnostics Not yet recruiting