Epigenetic Regulation of Epithelial to Mesenchymal Transition.

Epigenetic Regulation of Epithelial to Mesenchymal Transition.
Curr Cancer Drug Targets. 2013 Oct 29;
Authors: Huangyang P, Shang Y
Abstract
Epithelial-mesenchymal transition (EMT)is a vital process implemented inembryo development, organ fibrosis, and cancer metastasis.Several transcriptional factors and signaling pathways impinge on the transcriptional program of the cell, leading to the change of cell phenotype without alteration of genotype.Accumulating evidence suggests that epigenetic mechanisms play important roles in inducing EMT and orchest rating the heredity and reversibility of EMT. In this review, we discuss how DNA methylation, histone modifications, and microRNAs (miRNAs) act in a concertedmanner to regulate EMT. 'Epigenetic therapies'-inhibitors of DNA methyltransferases and histone deacetylases as well as microRNA are emerging as promising agents for cancer intervention.
PMID: 24168185 [PubMed - as supplied by publisher]

Source: Current Cancer Drug Targets - October 29, 2013 Category: Cancer & Oncology Authors: Huangyang P, Shang Y Tags: Curr Cancer Drug Targets Source Type: research