[Bronchial smooth muscle mitochondria: A new target for asthma therapy?]

[Bronchial smooth muscle mitochondria: A new target for asthma therapy?] Rev Mal Respir. 2020 Mar 02;: Authors: Esteves P, Celle A, Berger P, Trian T Abstract The main purpose of this review is to highlight mitochondria as a new therapeutic target to prevent bronchial smooth muscle (BSM) remodeling in asthma. Severe asthmatic patients, representing 5-10% of all asthmatics, are characterized by an increased BSM mass which is highly correlated with the severity of the disease and the rate of exacerbations. None of the current asthma therapies are effective in reducing BSM remodelling. This review, based on the current literature, reports the role of mitochondria in BSM, particularly in calcium signaling. PMID: 32139106 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research