Acid/bile exposure triggers TRAIL-mediated apoptosis in esophageal cancer cells by suppressing the decoy receptors and c-FLIPR.

In this study, we simulated GERD episodes in vitro by exposing the cancer cells to acid or acid/bile combination and found that the cancer cells lived through acid attacks by expression of the decoy receptors and c-FLIPR but died of TRAIL-mediated apoptosis when bile salts were present. Further investigation revealed that acid/bile exposure downregulated the decoy receptors and thereby facilitated TRAIL signaling; meantime, it inhibited protein kinase C activity and thus expedited c-FLIPR degradation, allowing apoptosis to take place.
PMID: 32135301 [PubMed - as supplied by publisher]

Source: The International Journal of Biochemistry and Cell Biology - March 1, 2020 Category: Biochemistry Authors: Meng X, Chang Z, Che N, Wu J, Dang T, Chai J Tags: Int J Biochem Cell Biol Source Type: research