Overview of Mathematical Modeling of Myocardial Blood Flow Regulation.

Overview of Mathematical Modeling of Myocardial Blood Flow Regulation. Am J Physiol Heart Circ Physiol. 2020 Mar 06;: Authors: Namani R, Lanir Y, Lee LC, Kassab GS Abstract The oxygen consumption by the heart and its extraction from the coronary arterial blood are the highest among all organs. Any increase in oxygen demand due to a change in the heart metabolic activity requires an increase in coronary blood flow. This functional requirement of adjustment of coronary blood flow is mediated by coronary flow regulation to meet the oxygen demand without any discomfort, even under strenuous exercise conditions. The goal of this article is to provide an overview of the theoretical and computational models of coronary flow regulation, and to reveal insights into the functioning of a complex physiological system which effects the perfusion requirements of the myocardium. Models for three major control mechanisms of myogenic, flow, and metabolic control are presented. These explain how the flow regulation mechanisms operating over multiple spatial scales from the pre-capillaries to the large coronary arteries yield the myocardial perfusion characteristics of flow reserve, autoregulation, flow dispersion, and self-similarity. The review not only introduces concepts of coronary blood flow regulation but also presents the state-of-the-art advances and their potential to impact the assessment of coronary microvascular dysfunction (CMD), cardiac-...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research