A Murine Model of Increased Coronary Sinus Pressure Induces Myocardial Edema with Cardiac Lymphatic Dilation and Fibrosis.

CONCLUSIONS: A novel surgical model of myocardial edema without infarct was established in mice. Cardiac lymphatics compensated by exhibiting both an acute dilatory and chronic growth response, that temporally differs between sexes. Transient myocardial edema was sufficient to induce a robust epicardial fibrotic and inflammatory response, again with distinct sex differences, which underscores the sex-dependent differences that exist in cardiac vascular physiology. PMID: 32142379 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research