Cross-neutralizing Anti-hemagglutinin Antibodies Isolated from Patients Infected with Avian Influenza A (H5N1) Virus.

Conclusions: Cross-reactive B cells of different germline origins could be activated and re-circulated by avian influenza virus. The HA stem epitopes targeted by the BnAbs, and the two Ab-encoding genes usage implied the VH1-69 and D3-9 are the ideal candidates triggered by influenza virus for vaccine development.
PMID: 32131957 [PubMed - in process]

Source: Biomedical and Environmental Sciences : BES - February 19, 2020 Category: Biomedical Science Authors: Sun Y, Cao Y, Li Z, Bai T, Zhang H, Hu SX, Li FC, Zhao X, Chen YK, Lu J, Liu LQ, Wang DY, Shu YL, Zhou JF Tags: Biomed Environ Sci Source Type: research