Control of Akt activity and substrate phosphorylation in cells

AbstractProtein kinase B/Akt is a serine/threonine kinase that links receptors coupled to the PI3K lipid kinase to cellular anabolic pathways. Its activity in cells is controlled by reversible phosphorylation and an intramolecular lipid ‐controlled allosteric switch. In this review, I outline the current progress in understanding Akt regulatory mechanisms, define three models of Akt activation in cells, and highlight how intramolecular allosterism cooperates with cell‐autonomous mechanisms to control Akt localization and activi ty and direct it toward specific sets of substrates in cells.

Source: IUBMB Life - March 7, 2020 Category: Research Authors: Ivan Yudushkin Tags: CRITICAL REVIEW Source Type: research