Cost-effectiveness analyses of interventions to improve osteoporosis care in France

ConclusionOur results suggest that structural interventions and indirect interventions to improve OP care (BMD and OP treatment prescription), in women 50  years old with a first fragility fracture, were dominant strategies.
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research

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Authors: Jeong C, Kim HJ, Lee S, Kang MI, Ha J Abstract Purpose: Denosumab is a monoclonal antibody that prevents the development of osteoclasts. The effect of denosumab in solid organ transplant recipients has been elucidated, but its effect in haematopoietic stem cell transplantation recipients has not been studied yet. The aim of this study was to determine the effectiveness and safety of denosumab in haematopoietic stem cell transplantation recipients. Methods: We retrospectively evaluated 33 female patients with osteoporosis (mean age 52.6 ± 9.8 years) following allogeneic haematopoiet...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Conclusions: Our algorithms were good at identifying matches for the prescribing physician according to our reference standard but may have included some false positives. Predicted probabilities from our models could be used in other databases where physician IDs are unavailable to help identify the prescriber.
Source: Medical Care - Category: Health Management Tags: Online Article: Applied Methods Source Type: research
No abstract available
Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Images Source Type: research
Conditions:   Spinal Cord Injuries;   Bone Resorption;   Osteoporosis Intervention:   Sponsor:   Yeungnam University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Bone is a dynamic structure, constantly built up by osteoblasts and torn down by osteoclasts. In youth there is a balance between these two cell types, but the processes of aging cause osteoclast activity to dominate, and thus bones inexorably lose density and strength. Osteoporosis lies at the end of this road. The research community has over the years investigated numerous possible approaches to force balance in the activity of osteoblasts and osteoclasts, and the work here is just one example of many. It is typical of most, in that it doesn't attempt to identify and address root causes, but instead seeks to intervene in...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Quantitative computer-aided analysis of chest CT scans can help clinicians...Read more on AuntMinnie.comRelated Reading: AAOS: QCT finds low bone density in lumbar fusion patients Software leverages CT scans to generate bone density data Quantitative lung CT refines COPD diagnosis in smokers QCT identifies bone loss after ob/gyn cancer treatment Automated QCT offers hope for passive osteoporosis screening
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
In this study, we demonstrated the effects of astaxanthin for differentiation to osteoblasts of MC3T3-E1 by the addition of acetaldehyde and Aldh2∗2 Tg mesenchymal stem cells in bone marrow. Astaxanthin restores the inhibited osteoblastogenesis by acetaldehyde in MC 3T3-E1 and in bone marrow mesenchymal stem cells of Aldh2∗2 Tg mice. Additionally, astaxanthin administration improved femur bone density in Aldh2∗2 Tg mice. Furthermore, astaxanthin improved cell survival and mitochondrial function in acetaldehyde-treated MC 3T3-E1 cells. Our results suggested that astaxanthin had restorativ...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
In this study, we attempted to investigate the effect of IGF-1 on the gene expression of intracellular Ca2+-handling proteins and figure out whether the intracellular Ca2+ signal affects IGF-1-induced osteogenic differentiation. We found that IGF-1 treatment significantly increased cell proliferation and induced cell morphological changes with an increase of cell surface area. Quantitative PCR and Western blot analysis showed that osteoblast marker proteins, including alkaline phosphatase (ALP), runt-related transcription factor 2 (RUNX2) and osteocalcin (OCN) were significantly upregulated by IGF-1 treatment, indicating I...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
This study aimed to find a new compound that would have a better anti-osteoporotic effect than that of berberine. Based on structure and activity relationship study, we identified compound 2c, a berberine derivative, to be the most potent compound to affect osteoblast differentiation. Compound 2c was more effective than berberine and exhibited no toxicity within its effective concentration. Compound 2c increased, in a dose-dependent manner, ALP activity during osteoblast differentiation and enhanced the mRNA expression of osteogenic factors including ALP, Runx2, and Osterix. Furthermore, compound 2c increased the transcrip...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
ABSTRACTPlastin 3 (PLS3), encoded byPLS3, is a newly recognized regulator of bone metabolism and mutations in the encoding gene result in severe childhood ‐onset osteoporosis. Since an X chromosomal gene,PLS3 mutation ‐positive males are typically more severely affected while females portray normal to increased skeletal fragility. Despite the severe skeletal pathology, conventional metabolic bone markers tend to be normal and are thus insufficient in diagnosing or monitoring patients. Our study aimed to explore serum microRNA (miRNA) concentrations in subjects with defective PLS3 function to identify novel markers that...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
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