Study of cytogenetic alterations and association with prognostic factors in Indian children with B lineage acute lymphoblastic leukemia

The treatment and outcome in acute lymphoblastic leukemia (ALL) is dependent on risk stratification, based on certain prognostic factors including the leukemia subtype, severity of disease in terms of leukocyte count, age at diagnosis& presence of favourable/ unfavourable cytogenetic alterations, including recurrent translocations. In addition, cellular response to the initial treatment also plays guiding role in continuation or intensification of the chemotherapy. The discovery of genetic alterations like BCR-ABL1 and subsequent development of risk stratification strategies and targeted therapy has played a major role in decreasing disease related deaths (1).
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research