Can the diastolic pulmonary pressure gradient provide cardiopulmonary capacity information in patients with pulmonary hypertension and left heart disease?

The study of Dragu R et al. published recently in International Journal of Cardiology [1] aroused our great interest. In order to further understand the influence of different hemodynamic methods, we observed the evaluation of exercise capacity in combined post- and pre-capillary pulmonary hypertension (Cpc-PH) patients. Fifty patients with PH due to left heart disease (PH-LHD) who underwent right heart catheterization and cardiopulmonary exercise test (CPET) were divided into Cpc-PH according to PVR  > 3WU or DPG ≥ 7 mmHg or trans-pulmonary gradient (TPG) ≥ 12 mmHg, respectively.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Letter to the editor Source Type: research

Related Links:

Objectives: We investigated whether concentrations of circulating microRNAs differ across the hypertensive right ventricle and pulmonary circulation, and correlate with hemodynamic/echocardiographic variables in patients with pulmonary arterial hypertension versus nonpulmonary arterial hypertension controls. Design: Prospective blood collection during cardiac catheterization from the superior vena cava, pulmonary artery, and ascending aorta in 12 children with pulmonary arterial hypertension and nine matched nonpulmonary arterial hypertension controls, followed by an unbiased quantitative polymerase chain reaction arr...
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Feature Cardiac Intensive Care Source Type: research
Pulmonary hypertension (PH) describes a heterogeneous set of diseases associated with increased morbidity and mortality, regardless of the aetiology [1–4]. The gold standard for diagnosing and phenotyping PH remains invasive measurement via right heart catheterisation [5]. Noninvasive estimation of pulmonary haemodynamics is an attractive alternative to reduce procedural risk and to more broadly study patient subsets who do not uniformly undergo right heart catheterisation for evaluation of PH (e.g. most patients with PH due to left heart disease) [5–7]. However, imperfect correlations between invasive and noni...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Editorials Source Type: research
Authors: Meoli DF, Clark DE, Davogustto G, Su YR, Brittain EL, Hemnes AR, Monahan K Abstract PURPOSE: Transpulmonary biomarkers may provide insight into pulmonary hypertension (PH) pathophysiology, but require cardiac catheterization. We investigated whether the peripheral arterial/venous ratio (PR) could substitute for the transpulmonary ratio (TPR). MATERIALS AND METHODS: Blood from the pulmonary artery (PA), pulmonary arterial wedge (PAW), peripheral venous, and peripheral arterial positions was analyzed for ET-1, NT-pro-BNP, and cAMP levels in subjects with no PH (n = 18) and PH due to left he...
Source: Biomarkers - Category: Research Tags: Biomarkers Source Type: research
Publication date: January 2020Source: Archives of Cardiovascular Diseases Supplements, Volume 12, Issue 1Author(s): M. Drissa, H. Jamila, H. DrissaBackgroundAtrial septal defect (ASD) is one of the most common causes of congenital heart disease manifested in adulthood and a subgroup of patients may not develop symptoms until late adulthood.Aim of studyThe aim of our study was to describe clinical and likelihood picture of adults over 60 years born with an ASD type II.MethodsWe performed a retrospective analysis of adult's ASD referred to our institution from 2010 through 2018. Clinical, electrocardiographic, echocardiograp...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
AbstractPulmonary arterial hypertension (PAH) related to left-to-right shunt can progress to Eisenmenger syndrome, a serious and fatal disease that is not yet curable. This pilot study considered stem cell injection as a new treatment modality in persistent pulmonary hypertension after the correction of a congenital heart defect. Three patients with persistent pulmonary hypertension after ventricular septal defect repair were included in this pilot study for a clinical trial. Mononuclear stem cells derived from patients ’ bone marrow specimens were injected into the right and left pulmonary arteries via cardiac cathe...
Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research
Conclusion: Exercise PAWP ≥21 mmHg unmasks occult LHD and is a frequent finding in exercise PH.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary hypertension Source Type: research
Conclusions: We developed a new preclinical model of Group 2 PH and showed that MetS exacerbates SAB-induced PH-LHD. We displayed that IL-6 promotes SAB-induced pulmonary vascular remodeling and PH-LHD. We proposed IL-6 as a therapeutic target in Groups 2 PH
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Right ventricle Source Type: research
One of the biochemical pathways implicated in PAH is the prostacyclin chain. While prostacyclin is associated with vasodilation and may be provided as treatment, another component of this pathway, thromboxane, promotes vasoconstriction. Thromboxane is secreted mainly by platelets. However, platelets have not been adequately evaluated in PAHObjective: To compare platelet count and volume of PAH patients and controls (normopressoric, submitted to right heart catheterization (RHC) during PAH investigation)Methods: Retrospective analysis of PAH patients and controls of a single PAH center, evaluated for PAH diagnosis between 2...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary hypertension Source Type: research
Background: Patients with systemic sclerosis (SSc) are at high risk of developing pulmonary hypertension (PH) which crucially affects patients’ symptoms, quality of life and prognosis. The aim of this study was to analyse the impact of the new hemodynamic definition of precapillary PH as proposed at the 2018 World Symposium on PH in SSc-patients.Methods: SSc-patients were screened for PH using clinical assessments as WHO-functional class, 6 minute walking distance (6MWD) and right heart catheterisation. Patients were divided into hemodynamic subgroups according to their mean pulmonary arterial pressure (mPAP) values ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary hypertension Source Type: research
Abstract Pulmonary hypertension is a term used to describe a complex multifactorial group of conditions diagnosed by an elevated mean pulmonary artery pressure of 20 mm Hg or higher on right heart catheterization. The diagnosis of pulmonary hypertension in pregnancy is important, as it is associated with high rates of maternal morbidity and mortality, even with modern management. Diagnostic testing is important for establishing the diagnosis, type, and severity of pulmonary hypertension, which in turn, dictates treatment options. Echocardiographic assessment is the first step in diagnosis and the gold standard for...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
More News: Cardiac Catheterization | Cardiology | Heart | Heart Disease | Hypertension | Pulmonary Hypertension | Sports Medicine | Study