Astrocytes in paraventricular nucleus is a potential therapeutic target for ventricular arrhythmia with sympathoexcitation after acute myocardial infarction
Abnormal and excessive sympathoexcitation is closely associated with the pathogenesis and end organ damages in heart failure [1]. After acute myocardial infarction (AMI), sympathoexcitation worsens cardiac ischemia, critical ventricular arrhythmia with left ventricular (LV) remodeling [2]. Sympathetic nervous system is regulated by central nervous system, especially by rostral ventrolateral medulla (RVLM) and paraventricular nucleus (PVN) [3,4]. Previous studies have indicated that inflammation in the PVN causes sympathoexcitation after AMI [1,5].
Source: International Journal of Cardiology - Category: Cardiology Authors: Takuya Kishi Tags: Editorial Source Type: research
More News: Arrhythmia | Cardiology | Heart | Heart Attack | Heart Failure | Reflex Sympathetic Dystrophy | Study | Ventricular Arrhythmia