Sclerotherapy versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis.

CONCLUSIONS: The evidence, obtained from one randomised clinical trial at high risk of bias, is very uncertain on whether sclerotherapy has an influence on mortality and if it may decrease first upper gastrointestinal or oesophageal variceal bleeding in children. The evidence is very uncertain on whether sclerotherapy has an influence on congestive hypertensive gastropathy, incidence on gastric varices, and incidence of bleeding from gastric varices. Health-related quality of life was not measured. There were no serious events caused by sclerotherapy, and analysis of non-serious adverse events could not be performed due to lack of numerical data. The GRADE assessment of each outcome showed a very low-certainty evidence. The results of the trial need to be interpreted with caution. Larger randomised clinical trials, following the SPIRIT and CONSORT statements, assessing the benefits and harms of sclerotherapy compared with sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis are needed. The trials should include important clinical outcomes such as death, failure to control bleeding, and adverse events. PMID: 32133620 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research

Related Links:

The interplay of Hypertension, ACE-2 and SARS-CoV-2: Emerging data as the "Ariadne's thread" for the "labyrinth" of COVID-19. Hellenic J Cardiol. 2020 May 22;: Authors: Tsioufis C, Dimitriadis K, Tousoulis D PMID: 32450334 [PubMed - as supplied by publisher]
Source: Hellenic Journal of Cardiology - Category: Cardiology Tags: Hellenic J Cardiol Source Type: research
The sensory nerve was recently identified as being involved in regulation of bone mass accrual. We previously discovered that prostaglandin E2 (PGE2) secreted by osteoblasts could activate sensory nerve EP4 receptor to promote bone formation by inhibiting sympathetic activity. However, the fundamental units of bone formation are active osteoblasts, which originate from mesenchymal stromal/stem cells (MSCs). Here, we found that after sensory denervation, knockout of the EP4 receptor in sensory nerves, or knockout of COX-2 in osteoblasts, could significantly promote adipogenesis and inhibit osteogenesis in adult mice. Furthe...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Longest official mourning period in Spain ’s democracy; unrest grows in UK PM’s party over Dominic Cummings lockdown breach; WHO says Americas are new Covid-19 epicentre. Follow the latest updatesGlobal report: Germany to relax travel curbs as Spain mourns Covid-19 victimsTory unrest increases pressure on PM to sack Dominic CummingsAustralia coronavirus – liveCoronavirus latest: at a glance5.21amBSTIndonesia said Tuesday it is deploying 340,000 troops to clamp down on rampant social-distancing violations as coronavirus infections surge in the world ’s fourth most populous country, AFP reports.The mi...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Australia news UK news US news Infectious diseases Science Africa Middle East and North Africa Americas Asia Pacific Russia China Brazil Microbiology Medical research Europe Spain Source Type: news
Pan American Health Organization warns of ‘very tough’ weeks ahead; US approaches 100,000 deaths; New Zealand has fifth day with no casesCoronavirus – latest updatesSee all our coronavirus coverageThe Americas have emerged as the new centre of the coronavirus pandemic, the World Health Organization (WHO) has said, as a US study forecast deaths surging inBrazil and other Latin American countries through August.“Now is not the time for countries to ease restrictions,” Carissa Etienne, WHO director for the Americas and head of the Pan American Health Organization (PAHO), said via videoconference.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Brazil Chile Americas Infectious diseases Science Source Type: news
Authors: Tomiyama H, Shiina K Abstract The brachial-ankle pulse wave velocity (brachial-ankle PWV), which is measured simply by wrapping pressure cuffs around the four extremities, is a simple marker to assess the stiffness of the medium- to large- sized arteries. The accuracy and reproducibility of its measurement have been confirmed to be acceptable. Risk factors for cardiovascular disease, especially advanced age and high blood pressure, are reported to be associated with an increase of the arterial stiffness. Furthermore, arterial stiffness might be involved in a vicious cycle with the development/progression o...
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
CONCLUSION: The results of our study suggest that the enhancement of β-VLDL catabolism is the major mechanism for atheroprotective effects of EL in Tg rabbits. PMID: 32448826 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Conclusions: The visual field is more clearly exposed during submucosal tunneling when using the near-focus mode than when using traditional procedures. This technique appears to be more efficient and secure than the traditional ESTT procedure. PMID: 32449398 [PubMed - as supplied by publisher]
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
Authors: Watanabe S, Oda J, Nakahara I, Matsumoto S, Suyama Y, Hasebe A, Suzuki T, Tanabe J, Suyama K, Hirose Y Abstract Mechanical thrombectomy using a retrograde approach is performed for tandem occlusion of the internal carotid artery (ICA). In our patient, a guiding catheter was easily passed by the stenosed lesion despite severe stenosis at the ICA origin. Therefore, we aimed to recanalize the occlusion of the terminal ICA without angioplasty for the stenosed lesion. When contrast was injected, a massive extravasation of contrast from the C2 portion of the ICA was observed. It was speculated that the bleeding ...
Source: Neurologia Medico-Chirurgica - Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
Authors: Piraccini E, Calli M, Taddei S, Byrne H, Rocchi M, Maitan S PMID: 32449341 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Authors: Abdelhamid BM, Khaled D, Mansour M, Hassan MM Abstract BACKGROUND: Pain control in the morbidly obese has presented as an anesthetic challenge. The aim of this study is to assess the analgesic efficacy of ultrasound guided bilateral erector spinae block compared to bilateral subcostal transversus abdominis plane block. METHODS: Prospective randomized, double-blinded controlled study was conducted at Kasr Alainy Hospital on 66 patients scheduled for laparoscopic sleeve gastrectomy. Patients were randomly allocated into three groups and received general anesthesia: bilateral erector spinae block at the l...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
More News: Beta-Blockers | Bleeding | Brazil Health | Children | Chronic Pain | Clinical Trials | Conferences | Databases & Libraries | Gastroenterology | General Medicine | Hypertension | Liver | Liver Disease | Pain | Pediatrics | Study | Thrombosis | Upper Endoscopy | Urology & Nephrology