Huayu Pill ( 化瘀丸) Promotes Fluorescent Doxorubicin Delivery to Tumors in Mouse Model of Lung Cancer

AbstractObjective: To study the effect and mechanism of Huayu Wan ( 化瘀丸, HYW) in combination of chemotherapy of tumor treatment.Methods: HYW serum was added in Lewis cells to assess its impact on fluorescent doxorubicin delivery in vitro. Then, Lewis tumor cells was implanted in C57BL/6 mice via xenograft transplantation. Tumor growth was measured and signal intensity corresponding to blood flow was assessed by laser doppler perfusion imaging (LDPI). Finally, the effect of HYW on the effificacy of doxorubicin was studied.Results: HYW can improve the transfer of fluorescent doxorubicin into cells. The blood flow signal in the tumor tissues of the HYW group was higher than that of the control group (P
Source: Chinese Journal of Integrative Medicine - Category: Internal Medicine Source Type: research

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Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
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Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
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In this study we used unbiased approach in the lung cancer and colon cell lines (A549 and HTC 116 respectively) to identify universal early transcriptomic signatures of C-1305 cytotoxicity, and to highlight novel pathways responsible for its biological activity. The data obtained with real time analysis was used to select appropriate doses for subsequent RNAseq and biochemical analysis. Furthermore, the RNA samples prior RNA-seq analysis were pre-verified for transcriptomic activation of apoptosis related pathways via qPCR . Since our real time analysis of cell growth have shown that 24 h exposure to C-1305 (at IC50 concen...
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Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
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