Keyboard design for phase I drug-combination trials

The Keyboard design is a novel model-assisted dose-finding method to find the maximum tolerated dose (MTD) for single-agent trials. The Keyboard design is easy to implement and has superior performance in comparison to more complicated model-assisted designs. In this article, we extend the Keyboard design to dual-agent dose-finding trials. The proposed Keyboard combination trial design maintains the simplicity of the original single-agent Keyboard design, and its dose escalation and deescalation rules can be pre-tabulated before conducting the trial.

Source: Contemporary Clinical Trials - March 5, 2020 Category: Radiology Authors: Haitao Pan, Ruitao Lin, Yanhong Zhou, Ying Yuan Source Type: research