On biological availability dependent bone remodeling.

On biological availability dependent bone remodeling. Comput Methods Biomech Biomed Engin. 2020 Mar 04;:1-13 Authors: Papastavrou A, Schmidt I, Steinmann P Abstract Modeling the evolution of bone density is relevant for understanding, simulation and possible prediction of bone response to external and internal influences. In this work we present a formulation for the bone density evolution process that takes into account not only the commonly considered mechanical stimulus, but, as novelty, also the influence of the availability of nutrients and hormones, with its implementation pursued within the finite element method. A simple uni-axial extension test is used to illustrate and compare our novel model against the classical approach. The results of the proposed modified model are promising for application to real-life problems. PMID: 32126825 [PubMed - as supplied by publisher]
Source: Computer Methods in Biomechanics and Biomedical Engineering - Category: Biomedical Engineering Authors: Tags: Comput Methods Biomech Biomed Engin Source Type: research