Clonal evolution after allogeneic stem cell transplantation: the case of myelofibrosis

Myelofibrosis (MF) is a clonal myeloproliferative neoplasm (MPN) that occurs in a primary form (PMF), or develops during progression of essential thrombocythemia (ET, post-ET MF) or polycythemia vera (PV, post-PV MF). MF results in insufficient hematopoiesis, bone marrow fibrosis, and extramedullary hematopoiesis. It can be accompanied by splenomegaly, hepatomegaly, pulmonary fibrosis, and constitutional symptoms. Circulating blasts are observed. Although the clinical course is heterogeneous, the prognosis of MF is poor with a high rate of transformation into blast phase.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research