Study on structure-activity relationship of vitamin K derivatives: Conversion of the naphthoquinone part into another aromatic ring and evaluation of their neuronal differentiation-inducing activity.

Study on structure-activity relationship of vitamin K derivatives: Conversion of the naphthoquinone part into another aromatic ring and evaluation of their neuronal differentiation-inducing activity.
Bioorg Med Chem Lett. 2020 Feb 24;:127059
Authors: Yoshimura H, Hirota Y, Soda S, Okazeri M, Takagi Y, Takeuchi A, Tode C, Kamao M, Osakabe N, Suhara Y
Abstract
We synthesized novel vitamin K derivatives by converting the naphthoquinone group to benzene derivatives and benzoquinone. We evaluated their neuronal differentiation activities to investigate the effect of the quinone moiety on this process. We observed that the 1,4-quinone as well as the side chain part play important roles in neuronal differentiation. We also performed QSAR analysis to predict the compounds which would have higher differentiation activity.
PMID: 32127260 [PubMed - as supplied by publisher]

Source: Bioorganic and Medicinal Chemistry Letters - February 23, 2020 Category: Chemistry Authors: Yoshimura H, Hirota Y, Soda S, Okazeri M, Takagi Y, Takeuchi A, Tode C, Kamao M, Osakabe N, Suhara Y Tags: Bioorg Med Chem Lett Source Type: research