Primary Hyperparathyroidism Presenting as Posterior Reversible Encephalopathy Syndrome: A Report of Two Cases

We report two cases of adolescent PHPT presenting with generalized tonic-clonic seizures and altered sensorium. On evaluation, both had hypertension, severe hypercalcemia (serum calcium 14.1 mg/dl and 14.5 mg/dl, respectively) and elevated parathyroid hormone levels. Magnetic resonance imaging revealed T2/FLAIR hyperintensities located predominantly in the parieto-occipital regions, suggestive of PRES. Localization and excision of parathyroid adenoma led to restoration of normocalcemia. Neurological symptoms and MRI changes improved subsequently. Extensive literature search revealed only four cases of PHPT-associated PRES; none of them being in the pediatric/adolescent age group. The predominant clinical manifestations were seizures and altered sensorium. All had severe hypercalcemia; three had hypertension at presentation while one was normotensive. Parathyroid adenomectomy led to normalization of serum calcium and resolution of neurological symptoms and radiological changes. Thus, severe hypercalcemia, although rare in PHPT, can lead to hypercalcemic crisis precipitating acute hypertension that can result in cerebral endothelial dysfunction with breakdown of blood-brain barrier, culminating in PRES. We therefore recommend that serum calcium levels should be checked in all patients with PRES and PHPT be regarded as a differential diagnosis in those with underlying hypercalcemia. PMID: 32129057 [PubMed - as supplied by publisher]
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research