Cyclic derivatives of morphiceptin possess anti-transit effect in the gastrointestinal tract and alleviate abdominal pain in mice.

CONCLUSIONS: Compound 1 is equally effective as P-317 in the mouse GI tract. The peptide bond reduction decreased the activity of compound 2. Fluorination appears to be an efficient way to increase the effects of morphiceptin analogs in the GI tract.
PMID: 32125684 [PubMed - as supplied by publisher]

Source: Pharmacological Reports - March 2, 2020 Category: Drugs & Pharmacology Authors: Szymaszkiewicz A, Włodarczyk J, Mazur M, Olczak J, Fichna J, Zielińska M Tags: Pharmacol Rep Source Type: research