A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol

Nature, Published online: 04 March 2020; doi:10.1038/s41586-020-2076-4Haploid genetic screening of cells under different types of mitochondrial perturbation shows that a pathway involving OMA1, DELE1 and the eIF2α kinase HRI communicates mitochondrial stress to the cytosol to trigger the integrated stress response.

Source: Nature AOP - March 3, 2020 Category: Research Authors: Evelyn Fessler Eva-Maria Eckl Sabine Schmitt Igor Alves Mancilla Matthias F. Meyer-Bender Monika Hanf Julia Philippou-Massier Stefan Krebs Hans Zischka Lucas T. Jae Source Type: research