Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway

Nature, Published online: 04 March 2020; doi:10.1038/s41586-020-2078-2A genome-wide CRISPR interference screen shows that a signalling pathway involving OMA1, DELE1 and the eIF2α kinase HRI relays mitochondrial stress to the cytosol to trigger the integrated stress response.

Source: Nature AOP - March 3, 2020 Category: Research Authors: Xiaoyan Guo Giovanni Aviles Yi Liu Ruilin Tian Bret A. Unger Yu-Hsiu T. Lin Arun P. Wiita Ke Xu M. Almira Correia Martin Kampmann Source Type: research