Radiologists are performing more bone marrow biopsies

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Source: Headlines - Category: Radiology Source Type: news

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This study was performed on 80 patients referred to Vali-e-Asr Hospital for bone marrow biopsy. Samples were selected by convenience method and were assigned into intervention and control groups using randomized blocks of 4. Random sequence was generated by RAS software. Several drops of distilled water on a cotton ball was used in the control group and same amount of lavender essential oil on a cotton ball was used in the intervention group. Then, participants in both groups were asked to smell the cotton ball for 15 minutes and then, their anxiety level was measured immediately. The results were analyzed by SPSS software...
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Clinical and biological presentation of patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) is depicted to highlight criteria that might alert physicians. Diagnosis of BPDCN is still challenging and requires (1) immunophenotyping of blood or bone marrow aspiration using several markers (CD4, CD56, HLA-DR, myeloid and lymphoid lineage markers) and should include pDC markers such as CD123, cTCL1, CD303, and CD304, and/or (2) pathologic analysis of cutaneous lesions, also with immunohistochemistry using markers specific to BPDCN.
Source: Hematology/Oncology Clinics of North America - Category: Cancer & Oncology Authors: Source Type: research
We want to thank our colleagues for this letter and for the great interest they have expressed.1,2 We agree that the diagnosis of solitary plasmacytoma is an important point; therefore, we followed the recommendations for diagnosis and treatment.3-5 We included only solitary plasmacytomas that were confirmed histologically with a biopsy and clinical workup and were absent of any features of multiple myeloma, according to guidelines.4 In particular, bone marrow biopsies were systematically performed to eliminate multiple myeloma (MM) at diagnosis and in the event of suspected myeloma progression or relapse of a new solitary plasmacytoma.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comment Source Type: research
We read the article “Solitary plasmacytoma: Lenalidomide-dexamethasone combined with radiation therapy improves progression-free survival and multiple myeloma-free survival” with great interest.1 It offers a combined treatment for solitary plasmacytoma (SP), which has a significant risk of progression to multiple m yeloma (MM). The diagnosis of SP and elimination of MM should include biopsies from the primary lesion and bone marrow (BM), multiparameter flow cytometry, serum and urine electrophoresis, immunoglobulins (Ig), Free Light Chain assay, Bence-Jones proteins, and skeletal survey with magnetic resonance ...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comment Source Type: research
A girl diagnosed with neuroblastoma at 33 months underwent 123I-MIBG scan after surgery and chemoradiotherapy. Although MIBG scan showed complete response, the bone marrow biopsy showed refractory disease. Therefore, she underwent 68Ga-DOTATATE PET/CT, which revealed bone marrow involvement and 68Ga-DOTATATE–avid brain metastasis. Rare physiological pineal gland uptake was also depicted. 68Ga-DOTATATE PET/CT showed active progressive disease earlier, before it was detectable with MIBG scan. For patients with MIBG-negative relapsed/refractory disease, 68Ga-DOTATATE may have an important role in restaging, detecting un...
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
We present the case of a 67-year-old man with prostate cancer who had no findings of recurrence, except diffuse radiotracer uptake in the bone marrow in 68Ga-PSMA PET/CT. Bone marrow uptake was also represented as multiple focal increased spots without any corresponding lytic or sclerotic lesions in CT. MRI revealed a high and homogeneous T2 signal within the bone marrow, without any contrast-enhanced or diffusion-restricted lesions. Further workup, including a bone marrow biopsy, revealed the diagnosis of myelodysplastic syndrome.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Clozapine-induced anemia: A case-report
. Int J Clin Pharmacol Ther. 2020 Mar 08;: Authors: Eleftheriou G, Butera R, Barcella L, Falanga A Abstract Clozapine, an atypical antipsychotic, can cause potentially life-threating side effects such as agranulocytosis. Our case presents a picture of severe anemia without any depression of the white cells or platelet lines. A 36-year-old man with treatment-resistant schizophrenia was admitted to the Psychiatric Unit for therapy assessment. After admission, he was gradually switched to clozapine treatment, 400 mg/d. General laboratory test results were nor...
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
Abstract BACKGROUND: We aimed to investigate the association of bone marrow mast cell numbers (MCN) and the degree of reticulin fibrosis in patients with chronic myeloproliferative neoplasms (MPN). METHODS: This was a case-control study that recruited 47 patients who were diagnosed with bcr-abl negative MPN. Thirty patients with lymphoma served as controls. JAK2 mutation was studied and all subjects underwent bone marrow biopsy at the time of diagnosis. Mast and CD34+ cells were counted. Marrow reticulin fiber was graded. RESULTS: Thirty-four patients had essential thrombocythemia (ET), 8 patients had pr...
Source: Blood Cells, Molecules and Diseases - Category: Hematology Authors: Tags: Blood Cells Mol Dis Source Type: research
Authors: Funada M, Nakano K, Miyata H, Nawata A, Tanaka Y Abstract We herein report a 65-year-old man with elevated serum IgG4 levels, enlarged thyroid, and renal dysfunction, mimicking IgG4-related disease (IgG4-RD). The definitive diagnosis of IgG4-RD was not established because a tissue biopsy revealed no IgG4-positive cell infiltration or fibrosis. The presence of an M peak in the β fraction, Bence Jones protein in urine, and progressive anemia suggested multiple myeloma (MM). The κ/λ ratio was>100, tumor plasma cells were present at>20% in bone marrow, and immunostaining revealed IgG4-p...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: Available online 3 March 2020Source: Journal of the American College of RadiologyAuthor(s): Osman Ahmed, Vibhor Wadhwa, Mikin V. Patel, Ketan Patel, Alexander Lionberg, Wesley Klejch, Adolfo Lizardo, Michael Ginsburg
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
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