Genetic Influence on Efficacy of Pharmacotherapy for Pediatric Attention-Deficit/Hyperactivity Disorder: Overview and Current Status of Research

This article reviews childhood ADHD pharmacogenomics efficacy studies published during the last decade (2009 –2019), which have largely focused on pharmacodynamic candidate gene investigations of methylphenidate and atomoxetine response, with a smaller number investigating pharmacokinetic candidate genes and genome-wide approaches. Findings from studies which have advanced the field of ADHD pharmacogenom ics through investigation of meta-analytic approaches and gene–gene interactions are also overviewed. Despite recent progress, no one genetic variant or currently available pharmacogenomics test has demonstrated clinical utility in pinpointing the optimal ADHD medication for a given individual pat ient, highlighting the need for further investigation.
Source: CNS Drugs - Category: Neurology Source Type: research