Addendum: Drug Interaction between Opioids and Oral P2Y12 Platelet Inhibitors

Date: March 9, 2020
Issue #: 
1593Summary: 
Opioids delay gastric emptying and the absorption of many
oral drugs, including the P2Y12 inhibitors clopidogrel (Plavix,
and generics), prasugrel (Effient, and generics), and ticagrelor(Brilinta), which are commonly used for initial treatment of
acute coronary syndrome (ACS). An article in our February 25,
2019 issue reviewed studies showing that coadministration
of opioids delayed and decreased absorption of oral P2Y12
inhibitors and increased platelet reactivity. Recently published
clinical outcomes data may add to these concerns.

Source: The Medical Letter - February 28, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Brilinta cangrelor Clopidogrel Effient Kengreal Morphine Opioids Plavix Prasugrel ticagrelor Source Type: research