Exogenous carbon monoxide protects against mitochondrial DNA ‑induced hippocampal pyroptosis in a model of hemorrhagic shock and resuscitation.

In conclusion, treatment with CORM‑3 ameliorated impairments of locomotor and exploratory activities in a rat model of HSR. The mechanism may be associated with the inhibition of mitochondrial DNA‑induced pyroptosis via improvements in cell metabolism.
PMID: 32124959 [PubMed - as supplied by publisher]

Source: International Journal of Molecular Medicine - February 6, 2020 Category: Molecular Biology Authors: Fu L, Zhang DX, Zhang LM, Song YC, Liu FH, Li Y, Wang XP, Zheng WC, Wang XD, Gui CX, Kong XJ, Kang LQ Tags: Int J Mol Med Source Type: research