In Silico Cell-Type Deconvolution Methods in Cancer Immunotherapy.

In Silico Cell-Type Deconvolution Methods in Cancer Immunotherapy. Methods Mol Biol. 2020;2120:213-222 Authors: Sturm G, Finotello F, List M Abstract Several computational methods have been proposed to infer the cellular composition from bulk RNA-seq data of a tumor biopsy sample. Elucidating interactions in the tumor microenvironment can yield unique insights into the status of the immune system. In immuno-oncology, this information can be crucial for deciding whether the immune system of a patient can be stimulated to target the tumor. Here, we shed a light on the working principles, capabilities, and limitations of the most commonly used methods for cell-type deconvolution in immuno-oncology and offer guidelines for method selection. PMID: 32124322 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research