Effect of inhaled acetone concentrations on exhaled breath acetone concentrations at rest and during exercise
Real-time measurements of the differences in inhaled and exhaled, unlabeled and fully deuterated
acetone concentration levels, at rest and during exercise, have been conducted using proton transfer
reaction mass spectrometry. A novel approach to continuously differentiate between the inhaled and
exhaled breath acetone concentration signals is used. This leads to unprecedented fine grained data
of inhaled and exhaled concentrations. The experimental results obtained are compared with those
predicted using a simple three compartment model that theoretically describes the influence of
inhaled concentrations on exhaled breath concentrations for volatile organic compounds with high
blood:air partition coefficients, and hence is appropriate for acetone. An agreement between the
predicted and observed concentrations is obtained. Our results highlight that the influence of the
upper airways cannot be neglected for volatiles with high blood:air partition coefficients, i.e.
highly water s...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Clemens Ager, Pawel Mochalski, Julian King, Chris A Mayhew and Karl Unterkofler Source Type: research