Certain interleukin polymorphisms might influence predisposition to lung cancer: A meta ‐analysis of 35 published studies

AbstractInterleukin polymorphisms might influence predisposition to lung cancer (LC), but the results of already published studies regarding the relationship betweeninterleukin polymorphisms and LC were still controversial and ambiguous. So the authors designed this meta ‐analysis to more precisely estimate relationship betweeninterleukin polymorphisms and LC by pooling the results of already published related studies. The authors searched Pubmed, Embase, Web of Science, and CNKI for already published studies. Thirty ‐five already published studies were pooled and analyzed in this meta‐analysis. The pooled meta‐analyses results showed that distributions ofIL ‐4 rs2243250 polymorphism among patients and controls from Asian countries differed significantly (dominant comparison: OR = 1.29, 95% CI 1.07 –1.55; overdominant comparison: OR = 0.83, 95% CI 0.73–0.95; allele comparison: OR = 1.26, 95% CI 1.03–1.54), and distributions ofIL ‐10 rs1800872 polymorphism among patients and controls from Caucasian countries also differed significantly (recessive comparison: OR = 0.54, 95% CI 0.35 –0.83; overdominant comparison: OR = 1.26, 95% CI 1.05.1.51). No genotypic distribution differences were observed forIL ‐4 rs2070874,IL ‐6 rs1800795,IL ‐6 rs1800796,IL ‐8 rs4073,IL ‐10 rs1800871, andIL ‐10 rs1800896 polymorphisms in pooled meta ‐analyses. This meta‐analysis suggested thatIL ‐4 rs2243250 might influence predisposition to LC in Asians, whereasIL ...
Source: IUBMB Life - Category: Research Authors: Tags: RESEARCH COMMUNICATION Source Type: research