Development and validation of autophagy ‐related‐gene biomarker and nomogram for predicting the survival of cutaneous melanoma

AbstractAutophagy plays a critical role in cutaneous melanoma, but the prognostic research of differentially expressed autophagy ‐related genes (DEARGs) in melanoma is lacking. Therefore, autophagy‐related gene expression data of 630 melanoma patients were obtained from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas database. The DEARGs were identified by “limma” package in R software. Best survival analysi s and the least absolute shrinkage and selection operator method were performed to identify a robust 7‐DEARG signature as well as construct nomogram associated with the clinical characteristics and validation in internal and external sets. This 7‐DEARG signature could be regarded as an independe nt prognostic signature in clinical setting, and nomogram may supply a more simple and accurate prediction for the prognosis of melanoma. Moreover, 5 cancer hallmarks and 18 potential compounds are commonly enriched in high‐risk expression phenotype. Thus, our finding provides new clinical evidenc es for the accurate diagnosis and identifies a potential prognostic autophagy‐related marker for the treatment of melanoma.
Source: IUBMB Life - Category: Research Authors: Tags: RESEARCH COMMUNICATION Source Type: research