Targeting alveolar macrophages shows better treatment response than deletion of interstitial macrophages in EGFR mutant lung adenocarcinoma

ConclusionsThese results suggest that the reduction of AMs has a stronger impact on restricting tumor progression compared with targeting IMs. The depletion of AMs leads to an elevated infiltration of CD8+ T cells into the lung that might be responsible for tumor growth impairment. Altogether, elimination of AMs is a better strategy to reduce EGFR mutant tumor growth and is less toxic, suggesting the selectively targeting of AMs to complement established therapies.

Source: Immunity, Inflammation and Disease - March 4, 2020 Category: Allergy & Immunology Authors: Kristina Alikhanyan, Yuanyuan Chen, Simone Kraut, Rocio Sotillo Tags: ORIGINAL RESEARCH Source Type: research