Resting energy expenditure in obese women with primary hypothyroidism and appropriate levothyroxine replacement therapy.

CONCLUSIONS: This study demonstrated that obese hypothyroid women in LT4 therapy with normal serum TSH level compared to euthyroid controls, are characterized by reduced REE, in line with the hypothesis that standard LT4 replacement therapy may not fully correct metabolic alterations related to hypothyroidism. We are not able to exclude that this feature may be influenced by the modulation of insulin sensitivity at the liver site, induced by LT4 oral administration.
PMID: 32119074 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - March 1, 2020 Category: Endocrinology Authors: Muraca E, Ciardullo S, Oltolini A, Zerbini F, Bianconi E, Perra S, Villa M, Cannistraci R, Castoldi G, Pizzi P, Manzoni G, Lattuada G, Perseghin G Tags: J Clin Endocrinol Metab Source Type: research