Challenges with wound infection models in drug development.

Challenges with wound infection models in drug development. Curr Drug Targets. 2020 Mar 01;: Authors: Shukla SK, Sharma AK, Gupta V, Kalonia A, Shaw P Abstract Wound research is an evolving science trying to unfold the complex untold mechanisms behind the wound healing cascade. In particular, interest is growing regarding the role of microorganisms in both acute and chronic wound healing. Microbial burden plays an important role in the persistence of chronic wound, ultimately resulting in delayed wound healing. It is therefore important for clinicians to understand the evolution of infection science and its various etiologies. Therefore, to understand the role of bacterial biofilm in chronic wound pathogenesis various in- vitro and in-vivo models are required to investigate biofilms in wound-like settings. Infection models should be refined comprising important signet of biofilms. These models are eminent for translational research to obtain data for designing an improved wound care formulation. However, all the existing models possess limitations and do not fit properly in the model frame for developing wound care agents. Among various impediments, one of the major drawbacks of such models is that the wound they possess does not mimic the wound human develops. Therefore, a novel wound infection model is required which can imitate the human wounds. This review article mainly discusses various in-vitro and in-vivo models showing micro...
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research